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OLIG2 oligodendrocyte transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 10215, updated on 2-Nov-2024

Summary

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Official Symbol
OLIG2provided by HGNC
Official Full Name
oligodendrocyte transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:9398
See related
Ensembl:ENSG00000205927 MIM:606386; AllianceGenome:HGNC:9398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BHLHB1; OLIGO2; RACK17; PRKCBP2; bHLHe19
Summary
This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 29.0) See more
Orthologs
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Genomic context

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See OLIG2 in Genome Data Viewer
Location:
21q22.11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33025935..33029185)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31394108..31397358)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34398243..34401493)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377136 Neighboring gene VISTA enhancer hs1188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18366 Neighboring gene long intergenic non-protein coding RNA 1690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34398072-34398974 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34405338-34406006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:34406007-34406674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34408273-34408826 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34408827-34409379 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:34414306-34415505 Neighboring gene long intergenic non-protein coding RNA 945 Neighboring gene oligodendrocyte transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity. Prata DP, et al. Hum Brain Mapp, 2013 Sep. PMID 22505278, Free PMC Article
  2. OLIG2 gene polymorphisms are associated with nasty, unpleasant and uncontrollable thoughts in obsessive-compulsive disorder. Vieira-Fonseca T, et al. J Clin Neurosci, 2019 Dec. PMID 31431405
  3. OLIG2 is a marker of the fusion protein-driven neurodevelopmental transcriptional signature in alveolar rhabdomyosarcoma. Raghavan SS, et al. Hum Pathol, 2019 Sep. PMID 31299267
  4. Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic-Ischemic Encephalopathy. Sun L, et al. Neuromolecular Med, 2019 Mar. PMID 30178266
  5. The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia. Yalcin A, et al. Exp Hematol, 2017 Nov. PMID 28760688

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking.
    Title: OLIG2 translocates to chromosomes during mitosis via a temperature downshift: A novel neural cold response of mitotic bookmarking.
  2. OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM).
    Title: OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM).
  3. Identifying an oligodendrocyte enhancer that regulates Olig2 expression.
    Title: Identifying an oligodendrocyte enhancer that regulates Olig2 expression.
  4. OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
    Title: OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma.
  5. Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.
    Title: Investigation of OLIG2 as a candidate gene for schizophrenia and autism spectrum disorder.
  6. Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.
    Title: Isocitrate Dehydrogenase Mutations Are Associated with Different Expression and DNA Methylation Patterns of OLIG2 in Adult Gliomas.
  7. The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells.
    Title: The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells.
  8. One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
    Title: One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
  9. Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?
    Title: Can oligodendrocyte transcriptional factor-2 (Olig2) be used as an alternative for 1p/19q co-deletions to distinguish oligodendrogliomas from other glial neoplasms?
  10. Profiling Glioblastoma Cases with an Expression of DCX, OLIG2 and NES.
    Title: Profiling Glioblastoma Cases with an Expression of DCX, OLIG2 and NES.
Submit: New GeneRIF Correction See all GeneRIFs (76)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables HMG box domain binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myelination IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron fate commitment IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spinal cord oligodendrocyte cell fate specification IEA
Inferred from Electronic Annotation
more info
  
involved_in thalamus development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oligodendrocyte transcription factor 2
Names
basic domain, helix-loop-helix protein, class B, 1
class B basic helix-loop-helix protein 1
class E basic helix-loop-helix protein 19
human protein kinase C-binding protein RACK17
oligodendrocyte lineage transcription factor 2
oligodendrocyte-specific bHLH transcription factor 2
protein kinase C-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011834.1 RefSeqGene

    Range
    5005..8255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005806.4 → NP_005797.1  oligodendrocyte transcription factor 2

    See identical proteins and their annotated locations for NP_005797.1

    Status: REVIEWED

    Source sequence(s)
    AF221520, BC047511
    Consensus CDS
    CCDS13620.1
    UniProtKB/Swiss-Prot
    B3KRF3, Q05BP9, Q13516, Q49AL3, Q86X04, Q9NZ14
    Related
    ENSP00000371794.3, ENST00000382357.4
    Conserved Domains (1) summary
    cd18940
    Location:95 → 179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    33025935..33029185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260908.2 → XP_005260965.1  oligodendrocyte transcription factor 2 isoform X1

    See identical proteins and their annotated locations for XP_005260965.1

    UniProtKB/Swiss-Prot
    B3KRF3, Q05BP9, Q13516, Q49AL3, Q86X04, Q9NZ14
    Related
    ENSP00000331040.3, ENST00000333337.3
    Conserved Domains (1) summary
    cd18940
    Location:95 → 179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    31394108..31397358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324300.1 → XP_054180275.1  oligodendrocyte transcription factor 2 isoform X1

    UniProtKB/Swiss-Prot
    B3KRF3, Q05BP9, Q13516, Q49AL3, Q86X04, Q9NZ14
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13516.2 GenPept UniProtKB/Swiss-Prot:Q13516

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